In rats, intravitreal injection of TNF- correlates with optic nerve degeneration and delayed death of retinal neuronal cells, associated with increased expression of NF-B p65 in the optic nerve, suggesting a link to TNF--induced axonal degeneration (165)
All these risk factors have a common characteristic, they are associated with a continuous state of oxidative stress and inflammation, excessive production of free radicals (reactive oxygen and nitrogen species) and endothelial cell dysfunction leading to cardiovascular disease and respiratory failure
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It plays a role in protecting the body from free radical oxidative stress, which can lead to premature aging of cells