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Biologically speaking, ideally, the biomaterial should be able to inhibit the degenerative processes, prevent the formation of nerve and blood vessels, and stimulate tissue regeneration

For the clinical assessment of posttraumatic disc degeneration there are currently two different main types of studies available employing MRI as surrogate for disc health

Preclinical observations in animal and cell culture studies have included enhanced cellular migration, increased markers of angiogenesis, and enhanced collagen deposition

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