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Integrative Psychiatry 2012 Sep 6 [cited 2021 Nov 24] 32

Symptoms include pain, swelling, and limited movement

Inspect previous sites regularly : Before applying a new patch, examine previous application sites for signs of skin reaction, including persistent redness, swelling, itching, or rash

Women in perimenopause experience menstrual irregularity and may have hot flashes, sleep difficulty, depressed mood or anxiety, and vaginal dryness, especially in late perimenopause