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In one study conducted in diet-induced obese mice, Reta not only led to significant reductions in body weightoften surpassing those seen with GLP-1-only therapiesbut also improved metabolic parameters such as insulin sensitivity, lipid profiles, and hepatic fat content

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These ROS trigger a cascade of detrimental effects: (1) transcriptional suppression of insulin via oxidative inactivation of PDX-1 and MafA, key regulators of insulin gene expression (Guo et al., 2023)

Despite not being FDA-approved for weight loss, Trulicity is sometimes prescribed off-label for this purpose