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In this view, the imbalance between commensals and pathogens (namely dysbiosis) would enhance the entry of bacterial and food antigens into the systemic circulation, triggering auto-aggressive processes [180]

These compounds are divided into two classes: those with direct antibacterial activity are called antimicrobial non-antibiotics, while the second group consists of helper compounds and macrophage modulators.1820 The most well-known non-antibiotic compounds are phenothiazines,21 chlorpromazine, thioridazine,22,23 the anti-inflammatory drug diclofenac,24 antihistamines such as promethazine and diphenhydramine, and cardiovascular drugs such as amlodipine, dobutamine, lacidipine, nifedipine, and oxyfedrine.2527 The exact mechanism of non-antibiotic action has not been determined but they have been proposed to modify cell permeability and affect potassium and calcium efflux pumps in susceptible bacteria

Role of coenzyme Q 10 in health and disease: an update on the last 10 years (20102020)