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These findings provide fundamental information that sheet-shaped GO nanostructures with protein coatings can adhere to cell surfaces and undergo size-dependent internalization, facilitating nanomedicine and nanotoxicity studies

Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging

HIF-1 activates glycolysis-related genes, including pyruvate dehydrogenase kinase 1 (PDK1), increasing the conversion of glucose to pyruvate and subsequently to lactate by inactivating PDH, which is considered critical for metabolic adaptation to hypoxia [74] [Figure 1F]

They work through fundamentally different mechanisms, which is why they're often combined