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Both classes exhibit pulmonary protective effects via systemic anti-inflammatory reprogramming, with clinical studies demonstrating reduced exacerbation risk in T2DM patients with comorbid COPD ( As previously discussed, metabolic imbalance and mitochondrial dysfunction under diabetic conditions are key mechanisms leading to lung injury

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Metformin promotes the survival of Random-Pattern skin flaps by inducing autophagy via the AMPK-mTOR-TFEB signaling pathway