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These mimic the actions of the hormone GLP-1 (short for glucagon-like peptide-1 receptors), which regulates blood sugar levels by stimulating insulin release

As a result, they help control blood sugar levels and manage weight

However, compounded injections must be measured and injected for each dose, and hence are safer as an in-office procedure

For GIPR whose ECL1 was loosely compacted by peptide 20, three residues (Y13 P -L14 P -D15 P ) strengthened the peptide-binding interface by forming a hydrogen bond with F127 1.29b and a salt bridge with R289 ECL2 , significantly stronger than that observed in GLP-1R and GCGR