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The consistency across different populations and healthcare systems strengthens the evidence for causation, particularly given the temporal relationship between drug initiation and NAION onset with many cases occurring within months of starting semaglutide

Type 1 Diabetes Warning: It is strictly not indicated for use in Type 1 Diabetes or to treat Diabetic Ketoacidosis (DKA)

By linking metabolic dysfunction, and specifically obesity-related adipokines, to local inflammation and tissue destruction strongly sustained by metalloproteinases (MMPs) and their inhibitors (Tissue Inhibitors of MetalloproteinasesTIMPs), we aim to outline translational strategies for precision-guided therapies in HS and to highlight future directions focused at integrating the influence of the "gut-skin axis" and metabolic factors on HS pathogenesis and the optimal response to drugs