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Acknowledgements We are grateful to all participants and acknowledge the support of the members of the RECAP study who contributed considerably to the data collection

MOTS-c is the more targeted tool for metabolic fat loss, particularly visceral fat driven by insulin resistance

CTCF, CEBP, EGR, E-box, AP-1, MITF, and NRF motifs had enrichment in the ATAC-seq groups and the expression of genes encoding TF of these families were significantly upregulated (i.e