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This has prompted concerns among menopause experts and GPs that both drugs could reduce the effectiveness of oral MHT medications although so far small studies have not shown that semaglutide impedes absorption of combined oral contraceptives

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Ho said the number roughly corresponds to the proportion of Californias population to the rest of the country.The nationwide number of semaglutide overdoses this year is more than double the 1,447 reported in 2022, which was more than double the 607 semaglutide overdoses reported in 2021.There were only 364 reported semaglutide overdoses in 2020 and 196 in 2019, less than 10% of the number that occurred so far this year.Americas Poison Centers released the data with a disclaimer that the figures likely represent an undercount in the number of cases involving semaglutide, as the center only included those voluntarily reported to poison control centers.It is an alarming trend from a poison center perspective, Ho said