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Triple agonism asks more of the body than monotherapy

The National Academies of Sciences, Engineering, and Medicine suggests general adequate intake of about 3.7 liters (125 ounces) daily for men and 2.7 liters (91 ounces) for women from all beverages and foods combined, though patients with heart failure or kidney disease may have fluid restrictions

Compared to bupropion-naltrexone, GLP-1 agonists were associated with a nine times higher risk of pancreatitis, or inflammation of the pancreas, which can cause severe abdominal pain