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Direct hormone replacement adds GH from the outside, which can bypass your pituitary entirely

Zabel BU, Naylor SL, Sakaguchi AY, Bell GI, Shows TB (November 1983)

(10) These proteins are often referred to as G-proteins, which, upon activation, might drive the generation of secondary messengers like cyclic adenosine monophosphate (cAMP) or inositol trisphosphate (IP3