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In the SUSTAIN 3, 7, and 10 trials, semaglutide was found to be superior to other GLP-1RAs at lowering glycated hemoglobin and body weight

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However, the same group reported decreased QA-immunoreactive microglia in the hippocampus, suggesting that QA expression in the brain may be region-specific or that hippocampal cell atrophy may have hindered its detection [63]