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At least in rats, they've shown, or was it mice, I think it might have been rats, but multiple studies showing that it's released from the cold in the brain

Yes, its very safe

doi: 10.3389/fimmu.2025.1662521 Received 09 July 2025 Revised 04 November 2025 Accepted 12 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Dieter Kabelitz, University of Kiel, Germany Reviewed by George Paltoglou, National and Kapodistrian University of Athens, Greece Anita Vergatti, University of Naples Federico II, Italy Updates Copyright 2025 Li, Xu, Wang, Peng and Liu

range 160-296g) initially did weigh more than females (183.6g