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Furthermore, increased circulating levels of Ang II disrupt blood-brain barrier (BBB) integrity, allowing circulating Ang II to access the brain parenchyma and trigger the AT 1 R directly, producing oxidative stress and brain inflammation ( 2 R is activated by Ang II and may counterbalance AT 1 R neurotoxic effects and determine a neuroprotective role in RAS activation, such as vasodilation, diuresis, anti-fibrosis, antihypertensive, and cognitive improvement

In an attempt to minimize the onset of oxidative stress, supplementation with various known antioxidants has been suggested

Darkening of the lips is caused by hyperpigmentation, this condition is usually caused by overabundance of melanin or overexposure to the sun