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Important Safety Reminders Medical Supervision Required: AOD-9604 should only be used under qualified medical supervision Baseline and monitoring laboratory testing is recommended Individual contraindications and health status must be evaluated AOD-9604 is not FDA-approved for any indication Contraindications and Precautions: Pregnancy and breastfeeding (no safety data available) Active malignancy (discuss with oncologist) Pediatric use (not studied in children) Significant organ dysfunction (limited safety data) Report Concerns: Any unexpected symptoms or adverse effects should be reported to your healthcare provider promptly

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Patients who underwent LP were younger (37vs42 years), less often were women (52.1%vs65.7%), more often were from middle income countries (32.3%vs10.3%), more frequently had decreased visual acuity (26.4%vs15.9%) and papilledema (30.6%vs14.5%;Table-1)