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232,233 Studies found that intracerebroventricular administration of GLP-1 in rodents can mediate satiety with no food present in the GIT and when gastric emptying is prevented

These changes were accompanied by inflammatory alterations in the intestinal mucosa and elevated levels of lipopolysaccharides (LPS), which activate TLR4-dependent inflammatory pathways and contribute to -cell damage (Vatanen et al., 2018)