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However, as explained above, GLP-1Rs are not only localized to organs involved in the glycemic response, such as the pancreas and the liver, but are also expressed in various regions of the brain through neurons and glial cells [108]

Beyond these metabolic effects, GLP-1RAs may exert direct actions on the cardiovascular system, including improved endothelial function, reduced inflammation, and modulation of atherosclerotic processes [4]

Nature 379, 6972

Many individuals prescribed these medications may have pre-existing risk factors for reflux, including obesity itself, which is a well-established independent risk factor for GORD