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GLP-1 RAs help by: Decreasing pro-inflammatory cytokine levels Reducing the Psoriasis Area Severity Index (PASI) Improving insulin sensitivity and reducing obesity (both of which exacerbate psoriasis) Wound Healing: In diabetic patients and others with chronic wounds, GLP-1 medications improve healing by: Reducing harmful MMP-9 levels and improving MMP-9/TIMP ratios Enhancing angiogenesis (new blood vessel formation) Normalizing C-reactive protein (CRP) levels, a marker of systemic inflammation Multi-System Anti-Inflammatory Effects of GLP-1 Medications GLP-1 agonists exhibit systemic anti-inflammatory effects across multiple organ systems: Cardiovascular: Reduces arterial plaque, improves endothelial function Renal: Protects glomeruli, reduces proteinuria, slows kidney disease progression Pulmonary: Reduces airway inflammation, potential benefits in asthma and COPD Liver (NAFLD/NASH): Lowers hepatic inflammation, improves liver enzymes GI/Metabolic: Reduces markers like IL-6 and CRP

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GLP-1R action on brown adipose tissue (BAT) thermogenesis In addition to causing changes in feeding, central GLP-1R activation may regulate body weight by increasing brown adipose tissue (BAT) thermogenesis (reviewed in Lockie et al., 2013)

Several studies/trials have reported a beneficial effect of weight loss on additional cardiovascular disease risk factors, including blood pressure, diabetes, and plasma lipid levels as well as a reduction in cardiovascular events