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Subsequently, we evaluated the levels of two crucial APAP-metabolizing enzymes, CYP2E1 and CYP1A2, revealing no significant differences in the protein expression levels and activities of CYP1A2 between hepsin / and wild-type mice either before or after APAP administration (Fig
Among the distinct tau transgenic mouse models, senescence was a robust and invariant response to tau accumulation that correlated with brain atrophy in mice and human PSP (35)
Dithiolethiones, a class of lipophilic organosulfur compounds, including 5-amino-3-thioxo-3H-(1,2)dithiole-4-carboxylic acid ethyl ester (ACDT) and 3H-1,2-dithiole-3-thione (D3T), have been found to activate Nrf2 signaling pathway and increase cystine/glutamate antiporter system (System Xc) and GSH levels in ferroptosis models [103, 104]
