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39 In addition, patients with extremely high serum acetaminophen concentrations (above a parallel line coinciding with a 4-hour postingestion concentration of 300 micrograms/mL or 2000 micromoles/L) were observed to have a 90% risk of developing hepatotoxicity

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Moreover, some other animal studies have reported a similar effect of riboflavin on SOD ( Reference Liang, Liu and Xu 23 , Reference Hirano, Hamajima and Horiuchi 34 , Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 ) , GPx ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Wang, Mei and Chen 36 ) and catalase ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Lee, Ye and Jones 37 ) activities

Some individuals experience optimal outcomes at intermediate doses, while others tolerate rapid escalation without difficulty