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Notably, NO and its derivatives (e.g., nitrite and nitrate) are more stable and less susceptible to rapid degradation under the antioxidant systems of serum 37 .The enzymatic antioxidants, including GPX, CAT, SOD and thioredoxin reductase (TrxR), play key roles in mitigating oxidative stress induced by ROS and free radicals 38

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Factors affecting the physical stability of peptide therapeutics. Interface Focus