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This suggests that while DSIP improves motor coordination, it may not directly ameliorate the specific asymmetry in motor behavior induced by ketamine in this stroke model

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The IGF-1/IGF-1R axis can also induce phosphorylation of ER through ribosomal S6 kinase 1 (S6K1), downstream of the PI3K/AKT/mTOR pathway which results in the upregulation of IGF-1, IGF-1R and other ER target genes (Kim et al., 2007)