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Moreover, findings from animal models demonstrate that fluctuations in SCFA levels often parallel renal function impairment, supporting the feasibility of using SCFAsparticularly butyrateas biomarkers in blood or feces (161, 176)

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Ferroptosis-related proteins have become attractive targets for many major human diseases that are currently incurable, and some ferroptosis regulators have shown therapeutic effects in clinical trials although further validation of their clinical potential is needed