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For example, NFAT5 activates mTOR-IRF3/7 to exacerbate kidney injury in patients and mouse models of lupus nephritis [51], and its interaction with NF-B enhances glycolysis and inflammatory responses in macrophages during sepsis [52]

Does mitochondrial iron depletion induce additional signaling or restorative pathways, either within the mitochondria or extending into the cytosol

A., Leavitt, L., & Sharma, S

Initial management typically involves conservative approaches, such as functional rest, application of ice, the use of nonsteroidal anti-inflammatory drugs (NSAIDs), and the adoption of sports footwear with soft insoles [8, 9]