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First, in the cytosol, VPA is activated and links with reduced acetyl coenzyme A (CoA-SH) to form valproyl-CoA (by the ATP-dependent medium-chain acyl-CoA synthetase, located on the outer side of the mitochondrial membrane)

GLP-1R agonists show great potential in AD, but key challenges, such as blood brain barrier (BBB) penetration, clinical trial inconsistency, long-term safety and precision therapy, need to be addressed

Both Mummichog and GeneSet Enrichment Analysis (GSEA) algorithms were utilized using MetaboAnalyst 5.0 [49, 50]