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Therapeutic targeting of ERAD and ER stress in metabolic diseases 4-Phenylbutyric Acid (4-PBA) Chemical chaperones such as 4-PBA have demonstrated beneficial effects in mouse models of obesity and diabetes, normalizing hyperglycemia and restoring systemic insulin sensitivity

247 In addition, p53 protein levels are elevated in senescent cells and exacerbate centromere inactivation through the negative regulation of CENP-A expression

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