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Last updated: March 22, 2026 Introduction to Inflammatory Bowel Disease The etiology of Inflammatory bowel disease (ulcerative colitis and Crohns disease) is complex, with genetic predisposition, an altered microbiome, environmental factors and a weakened epithelial (gut) barrier function triggering a chronic immune response in the mucosal layer

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49 Role of GH-IGF1 axis Obesity reduces the secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF1) from the liver

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