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The generated AGEs significantly impact the gut microbiota, characterized by an increase in Bacteroidetes , a decrease in Firmicutes abundance, and a reduced relative abundance of Lactobacillus , contributing to systemic inflammation in CKD (46)

Additionally, oxidative stress can impair the clearance mechanisms of A, including autophagy and proteasomal degradation, contributing to its accumulation [154]

J Cell Biochem 2008

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