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The native peptide GLP-1-G 2 ( 1 ) showed a decreased of blood glucose concentration after 30 min, proving its efficacy in vivo, although for a short time as a rapid raise to the initial concentration level is observed after 1 h

This delay contrasts with tirzepatide, which is currently accessible in the United States and has recently obtained approval in Europe.217 Adverse Reactions and Safety of GLP-1RAs and GLP-1/GIP Dual Receptor Agonist GLP-1RAs and dual agonists targeting GLP-1 and GIP receptors have demonstrated considerable efficacy in the treatment of T2DM and obesity

Kaku K, Haneda M, Tanaka Y, et al