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Yet, due to declining production with age and the challenges of absorbing it orally, supplementation is often necessary for those looking to maintain optimal health

In the Methods, we explain why we take the multiplier, S , of the V max values of GCL and GPX to have the following dependence on estradiol, E 2: Thus, since male E 2 is 0.09 nM [26] , S = 1 for the male