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(In 2024 research published in the Journal of the American Medical Association , participants who took tirzepatide for weight loss generally saw greater benefit from tirzepatide, compared to semaglutide.) The FDAs announcement explains how liraglutide works: Liraglutide improves blood sugar levels by creating similar effects in the body as GLP-1 in the pancreas, which is often found in insufficient levels in type 2 diabetes patients. They add that type 2 diabetes typically develops over many years as a chronic condition that occurs when the body does not use insulin well and cannot keep blood sugar at normal levels. New Jersey-based Hikma Pharmaceuticals USA Inc