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In mouse models, the team introduced combined therapy including PD-L1 blocker and cyst(e) inase (a bioengineered enzyme that degrades cystine and cysteine) and such treatment can enhance the efficacy of CTL-mediated anticancer effects, supporting the idea that inducing ferroptosis could be considered a productive way for treating cancer and overcoming immunotherapy resistance ( Merkel cell carcinoma (MCC) is a rare, malignant neuroendocrine cutaneous tumor ( Artemisia annua ( Drug resistance Cell dedifferentiation is one of the signs of tumor progression and promotes resistance to current therapies ( As mentioned above, erastin can directly bind to VDAC2/3 and cause ferroptosis

Es verdad que estos efectos suelen ser transitorios y mejoran al escalar la dosis lentamente