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Among patients with adrenal incidentalomas, 2030% meet the diagnostic criteria for mild autonomous cortisol secretion (MACS), and this proportion increases further with age, with up to 3050% of incidentalomas in individuals older than 6065 years exhibiting biochemical features of MACS [174]

It also suppresses expression of certain oncogenes such as HER-2/neu, contributing to its antitumor effects