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Retatrutide is an investigational once-weekly subcutaneous peptide that simultaneously activates GLP-1, GIP, and glucagon receptors to reduce appetite, increase energy expenditure, and promote fat breakdown, though it has not yet received MHRA or EMA authorisation

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The American College of Rheumatology (ACR) recommends early aggressive therapy to prevent irreversible joint damage and achieve remission or low disease activity using a treat-to-target approach with regular monitoring of disease activity measures