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In the STEP clinical trial program for semaglutide, involving over 4,500 participants, serious kidney-related adverse events were uncommon and typically associated with severe dehydration from gastrointestinal symptoms

Animals Adult male (n=68) and female (n=68) SpragueDawley rats were bred in house from breeding pairs obtained from Charles River, Quebec, Canada, after weaning rats were double-housed in a 12-h light/dark cycle

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Its proposed mechanisms include the enhancement of lipid metabolism, improvement of insulin sensitivity, stabilization of hepatocyte function, and reduction of inflammation, fibrosis, and tumorigenesis