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Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist

20 In a recent large-scale US observational registry study (n=175,667, average age 52 years, 61% female, median follow-up duration 45 months) specifically evaluating risk of HF, e-cigarette use was associated with a 19% excess risk of incident HF and particularly heart failure with preserved ejection fraction (HFpEF), even after adjustment for age, sex and traditional CV risk factors

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Media description (scene 6): The CVS Weight Management program app shows range of program support with images of healthy food, a scale and a provider