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This slight increase then leads to an increase in inflammatory cytokines (TNF-alpha, IL-1 beta) in macrophages[ref] Endoplasmic Reticulum (ER) stress, protein misfolding: The endoplasmic reticulum (ER) is an organelle in cells where newly synthesized proteins are folded, lipids are synthesized, and calcium is stored

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(ii) If the request is not compliant with the requirements of this section or requires additional information (A) CMS follows up with the ASM participant to request additional information in a form and manner as specified by CMS