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The majority of significant proteoforms were enriched in resilient brain compared to dementia

doi: 10.1038/cdd.2016.25 28 YangWSKimKJGaschlerMMPatelMShchepinovMSStockwellBR

Common symptoms include: Extreme, unexplained fatigue lasting longer than six months Post-exertional malaise (PEM) exhaustion after physical or mental effort Sleep that feels unrefreshing Muscle and joint pain Cognitive difficulties (brain fog) trouble concentrating or remembering things Frequent headaches Dizziness or lightheadedness upon standing (orthostatic intolerance) Sore throat or swollen lymph nodes Low stress tolerance or mood changes If you suspect youre experiencing CFS, certain lifestyle adjustments can help support your energy and reduce symptom flare-ups: Avoid overexertion and allow recovery time between activities

It is widely recognized that diabetes affects hippocampal synaptic plasticity, and this disruption in synaptic plasticity is related to cognition