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reported that allopurinol and nicotinamide inhibit the proliferation of OFs induced by superoxide ( in vitro study performed in cultured OFs from patients with GO, incubated with interferon (IFN-) and tumor necrosis factor (TNF-) in the presence of nicotinamide (47)

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While these average changes seem minimal, caution is warranted: if a patient has underlying high blood pressure or heart disease, even transient increases could be risky

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Can complement each other

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