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As this systematic review did not involve meta-analysis due to the heterogeneity of study designs, intervention protocols, and outcome measures, data were synthesized using a qualitative narrative synthesis approach

Certain peptidesespecially mitochondrial peptides such as MOTS-Cimprove: ATP production Metabolic resilience Exercise tolerance 4

The loss of the chondrocytic phenotype and proliferative potential during in vitro expansion, termed as dedifferentiation, has been well documented