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People who were overweight or obese lost significant weight while taking retatrutide, which enabled them to be more active and reduced knee pain by an average of 4.5 points or about 76% based on pain scores from whats known as the Western Ontario and McMaster Universities Osteoarthritis Index

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Rounding from 8.3 to 8 units at the 2.5mg dose gives you 2.4mg, a 4% decrease

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