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This hypothalamic factor exerts its action in the pituitary cells through the activation of GPCRs and the signaling by PLC and cAMP pathways (222, 223)

The limitation of our algorithm proposals is the lack of real-world data and well-designed clinical research investigating the efficacy and safety of antidiabetic medications in patients with CD and acromegaly, mainly due to the fact that the patient populations are small for these rare diseases

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