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CPS1 may enhance tumor cell proliferation, migration, and invasion by decreasing ammonia concentration in the tumor microenvironment and promoting autophagic flow(Zhang et al

Nagakura, I., Van Wart, A., Petravicz, J., Tropea, D

Science 370 , 856860 (2020)

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages