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Spatiotemporal regulation of the KEAP1-NRF2 system Under physiological conditions, KEAP1 is the main regulator of the NRF2 protein level (NRF2 has a half-life of about 20 min) [120, 145]

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Int J Mol Sci 23(9):5202 Fontanella RA et al (2024) Tirzepatide prevents neurodegeneration through multiple molecular pathways