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In another animal study, ashwagandha reversed paclitaxel-induced neutropenia in mice when administered for four days before paclitaxel treatment and continued for 12 days after treatment

This mechanism includes the inhibition of hepatic glycogen synthesis, the enhancement of hepatic gluconeogenesis, excessive production of branched-chain amino acids (BCAAs) that block insulin receptor substrates, the generation of dipeptidyl peptidase-4 (DPP4) which accelerates degradation of glucagon-like peptide-1 (GLP-1), thereby reducing GLP-1-mediated insulin secretion, and the induction of -cell dedifferentiation, which alters insulin production

PPAR, peroxisome proliferator-activated receptor-gamma

Both accelerate breakdown of many peptide chains