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Recent FDA Guidance on Compounded GLP-1s: In October 2023, the FDA issued warnings about compounded GLP-1 medications, specifically cautioning patients to ensure theyre receiving semaglutide (the actual FDA-approved ingredient) rather than semaglutide salts, which have different properties

Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner (Meurot et al., 2022)

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