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Glucagon is well characterized for its ability to increase hepatic glucose output, and additionally has been shown to reduce body weight and appetite, delay gastrointestinal transit, and stimulate insulin secretion under certain circumstances, for example in the presence of hypergly- cemia (Habegger et al., 2010;Mochiki et al., 1998;Song et al., 2017)
Mol Pharmacol 99:104113 Karhu ST, Vlimki MJ, Jumppanen M, Kinnunen SM, Pohjolainen L, Leigh RS, Auno S, Fldes G, Boije AF, Genns G, Yli-Kauhaluoma J, Ruskoaho H, Talman V (2018.) Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds
Wahibah et al., 2018)
Some are also approved to reduce the risk of major adverse cardiovascular events (MACE) like heart attack and stroke, support kidney protection, treat obstructive sleep apnea (OSA) via significant weight loss, and help with metabolic dysfunctionassociated steatohepatitis (MASH) in certain patients
![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
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