The Use of Low-Dose Naltrexone for Chronic Pain Kirbie M Bostick, Andrew G McCarter, Diane Nykamp PMID: 30821677 DOI: 10.4140/TCP.n.2019.43 Review:Med Sci (Basel) 2018 Sep 21;6(4):82
Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
From a side effects point of view, GLP-1R agonists can cause gastrointestinal disturbances, such as nausea and vomiting, which can become an issue in the long term as they can disrupt daily life. Furthermore, from an economic perspective, the chronic long-term use of GLP-1R agonists is very expensive for patients and healthcare systems, especially in the US, where the annual cost of therapy for a person taking Zepbound is over $13,000
What to eat while taking a GLP-1 Because you will most likely be eating less when taking a GLP-1, you want to prioritize foods that are nutrient-dense and help you feel your best
